Bullous Variant of Pyoderma Gangrenosum in a Patient with Acute Myeloid Leukemia

Ann Dermatol. 2022 Jun;34(3):212-215. doi: 10.5021/ad.2022.34.3.212. Epub 2022 May 20.


Unlike classic pyoderma gangrenosum (PG), the bullous variant of PG is typically represented by a painful erythematous papule, plaque, and superficial bulla that progress into the ulceration with bullous margin. Generally, bullous PG is most commonly associated with myeloproliferative disorders, such as acute myeloid leukemia (AML). Bullous PG in AML patients rarely occurs, but once it does, it suggests a poor clinical prognosis. Although many cases of classic PG in AML patients have been reported, bullous PG is relatively rare. Therefore, we present a case of bullous PG that developed in a patient with AML and was successfully treated with high-dose systemic steroids.

PMID:35721340 | PMC:PMC9171183 | DOI:10.5021/ad.2022.34.3.212