Elevated levels of sCD48 are inversely correlated with markers of disease activity in bullous pemphigoid

AbstractObjective

sCD48 is elevated in diseases characterized by IgE and eosinophilia, such as allergies and asthma. Serum levels sCD48 were evaluated in relation to clinical characteristics of Bullous pemphigoid (BP) patients.

Methods

sCD48 levels were determined by ELISA in sera from 26 patients with classic BP and 26 healthy controls. Disease severity scores, differential blood counts, and circulating autoantibody levels were obtained. A correlation analysis was performed to establish relationships between sCD48 and clinical and laboratory markers of disease severity.

Results

Overall, circulating levels of sCD48 were significantly elevated in BP patients; however, when stratified based on disease severity, patients with mild-moderate disease had higher levels of sCD48 than those with severe disease. A Spearman’s correlation analysis identified an inverse relationship between sCD48 and disease activity, serum BP180 IgE and peripheral eosinophil numbers.

Conclusion

sCD48 levels are inversely correlated with several key measures of disease activity in BP patients. Further studies are needed to determine the pathologic relevance of these findings.