Significant improvement of facial actinic keratoses after blue light photodynamic therapy with oral vitamin D pretreatment: An interventional cohort-controlled trial

This study demonstrates that patients with actinic keratosis of the face who are pretreated with high-dose oral vitamin D3 supplements prior to blue light PDT show significantly increased lesion clearance. A combination approach using oral Vitamin D3 pretreatment and an ultra-short 5-ALA incubation/blue light regimen is nearly painless and provides clearance rates of ?75% after a single treatment session.