Skin microbiome variation with cancer progression in human cutaneous squamous cell carcinoma

The skin microbiome plays a critical role in skin homeostasis and disorders. UV-radiation is the major cause for nonmelanoma skin cancer, but other risk factors including immune suppression, chronic inflammation, and antibiotic usage, suggest the microbiome as an additional, unexplored risk factor and potential disease biomarker. The overarching goal was to study the skin microbiome in squamous cell carcinoma (SCC) and pre-malignant actinic keratosis (AK) compared to healthy skin to identify skin cancer-associated changes in the skin microbiome.