Toward Cannabinoid Use for Refractory Cutaneous Dermatomyositis

Dermatomyositis (DM) is a rare but potentially devastating autoimmune disease typically characterized by myositis, interstitial lung disease, and a characteristic rash. DM, systemic lupus erythematosus, and scleroderma share some immunopathogenic pathways, and these diseases show clinical overlaps. Dysregulation of nucleic acid metabolism and disordered type I IFN production contributing to autoantibody production may be a common denominator across these disorders.