'RNA fishing' reveals new driver of melanoma malignancy and metastasis

Researchers have identified several proteins involved in the progression of melanoma. One of the proteins -- PDIA6 -- was found to be particularly important for driving malignancy. Experiments with mice showed that melanoma cells with reduced levels of PDIA6 had an impaired ability to metastasize to the lung. The findings could lead to new therapeutic strategies that prevent the spread of melanoma from one part of the body to another.